【專利讓與】METHOD FOR ANTI-OXIDATION, INHIBITING ACTIVITY AND/OR EXPRESSION OF MATRIX METALLOPROTEINASE, AND/OR PROMOTING EXPRESSION OF COLLAGEN USING IXORA PARVIFLORA LEAF EXTRACT(用於抗氧化、抑制基質金屬蛋白酶活性及/或生成、及/或促進膠原蛋白生成之白仙丹葉萃取物及其用途)

中國醫藥大學 研發成果讓與公告

本校案件

科技部成果公告讓與

公告日期

2020/8/25

發明人代表

中國醫藥大學 藥用化妝品學系 江秀梅老師

專利(技術)名稱

METHOD FOR ANTI-OXIDATION, INHIBITING ACTIVITY AND/OR EXPRESSION OF MATRIX METALLOPROTEINASE, AND/OR PROMOTING EXPRESSION OF COLLAGEN USING IXORA PARVIFLORA LEAF EXTRACT

專利國別

美國

專利核准日

2017.6.6

專利證號

US 9,669,064 B2

類型

發明

專利範圍

(英文)

1. A method for anti-oxidation, inhibiting the activity of matrix metalloproteinase (MMP), inhibiting the expression of matrix metalloproteinase, and/or promoting the expression of collagen in a mammal, comprising administering a medicament comprising an effective amount of an Ixora parviflora leaf extract to a mammal in need of at least one of the following: anti-aging, anti-photoaging, reducing skin wrinkles, and improving skin flaccidity caused by collagen decomposition, wherein the content of the Ixora parviflora leaf extract in the medicament ranges from about 0.03 wt % to about 0.4 wt % based on the total weight of the medicament.

2. The method as claimed in claim 1, wherein the absorption spectroscopy of the extract includes peaks within the following wavelength ranges: from 210 to 250 nm, from 260 to 290 nm, and from 300 to 350 nm.

3. The method as claimed in claim 1, wherein the absorption spectroscopy of the extract includes peaks within the following wavelength ranges: from 220 to 250 nm, from 270 to 290 nm, from 310 to 340 nm, from 390 to 420 nm, and from 650 to 670 nm.

4. The method as claimed in claim 1, wherein the extract is prepared by the following steps: a) extracting Ixora parviflora leaves with a polar solvent and collecting the liquid phase; and b) drying the collected liquid optionally, wherein the polar solvent is selected from a group consisting of water, C.sub.1-C.sub.4 alcohols, and combinations thereof.

5. The method as claimed in claim 4, wherein the polar solvent is selected from a group consisting of water, methanol, ethanol, propanol, butanol, propylene glycol, and combinations thereof.

6. The method as claimed in claim 4, wherein the polar solvent is methanol.

7. The method as claimed in claim 4, comprising, prior to step b), repeating step a) one or more times and combining all the liquid phase to provide the collected liquid for step b).

8. The method as claimed in claim 1, wherein the matrix metalloproteinase is selected from a group consisting of matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-9 (MMP-9), and combinations thereof.

9. The method as claimed in claim 1, wherein the collagen is Type I collagen.

10. The method as claimed in claim 1, which is for improving, repairing, and/or caring for skin.

11. The method as claimed in claim 1, which is for anti-photoaging.

12. The method as claimed in claim 11, which is for anti-photoaging induced by ultraviolet ray B (UVB).

專利範圍

1.一種白仙丹(Ixora parviflora )葉萃取物,其紫外-可見光吸收光譜係包含以下波長範圍之吸收峰:210至250奈米、260至290奈米、及300至350奈米。

2.如請求項1之萃取物,其紫外-可見光吸收光譜係包含以下波長範圍之吸收峰:220至250奈米、270至290奈米、310至340奈米、390至420奈米、及650至670奈米。

3.如請求項1之萃取物,其係以包含如下步驟之方法製得:a)使用一極性溶劑萃取白仙丹葉,以獲得一萃取液;以及b)視需要乾燥該萃取液,其中該極性溶劑係選自以下群組:水、C1 -C4 醇類、及前述之組合。

4.如請求項3之萃取物,其中該極性溶劑係選自以下群組:水、甲醇、乙醇、丙醇、丁醇、丙二醇、及前述之組合。

5.如請求項3之萃取物,其中該極性溶劑係甲醇。

6.如請求項3之萃取物,其中係於步驟b)之前,重複進行多次步驟a),且合併該多次步驟a)所得之萃取液以進行步驟b)。

7.如請求項1至6中任一項之萃取物,其係用於抗氧化、抑制基質金屬蛋白酶活性、抑制基質金屬蛋白酶生成、及/或促進膠原蛋白生成。

8.如請求項7之萃取物,其中該基質金屬蛋白酶係選自以下群組:基質金屬蛋白酶-1(MMP-1)、基質金屬蛋白酶-3(MMP-3)、基質金屬蛋白酶-9(MMP-9)、及前述之組合。

9.如請求項7之萃取物,其係用於改善、調理及/或修補皮膚。

10.一種用於抗氧化、抑制基質金屬蛋白酶活性、抑制基質金屬蛋白酶生成、及/或促進膠原蛋白生成之組合物,其係包含有效量之如請求項1至6中任一項之萃取物。

11.如請求項10之組合物,其係用於改善、調理及/或修補皮膚。

12.一種使用如請求項1至6中任一項之萃取物於製造藥劑之用途,其中該藥劑係用於抗氧化、抑制基質金屬蛋白酶活性、抑制基質金屬蛋白酶生成、及/或促進膠原蛋白生成。

13.如請求項12之用途,其中該藥劑係用於改善、調理及/或修補皮膚。

 

發佈留言

發佈留言必須填寫的電子郵件地址不會公開。 必填欄位標示為 *